ULTIMATE SPOT CREAM by COSRX. COSRX Ultimate Spot Cream provides a spot treatment for blemishes, blemishes and acne. This formula gently and effectively dries visible acne overnight using a skin recovery complex that combines Zinc Oxide, Calamine, CentellAC-RX Complex and Aloe Leaf Water. The particular mixture of Centella Asiatica extracts repairs damaged skin and acne scars. Zinc oxide, calamine, and aloe vera work together to soothe irritated skin and prevent new infections.